The Legumain Polyclonal Antibody from Bioss Inc. is a Rabbit Polyclonal antibody to Legumain, and LGMN. This antibody recognizes Human, Mouse, and Rat antigen. The Legumain Polyclonal Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system